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Food;Pharmaceutical Additives

Hydroxypropyl Beta Cyclodextrin

Product Name:Hydroxypropyl Beta Cyclodextrin

Other name : hydroxypropyl betadex ; 2-hydroxypropyl-beta-cyclodextirn ; Hydroxypropyl-β-cyclodextrin .

Abbreviation : HPBCD

CAS: 128446-35-5; 94035-02-6; 136019-12-0

EINECS: 420-920-1

Molecular formula :C42H70-nO35(C3H8O2)n

Molecular weight: 1134.98+58n

Qaulity :Pharma grade /injection grade/ food grade / cosmetics grade / industry grade 

Standard : USP40/ EP9.0/ CP2015

Package: 500g/bag , 2kg/bag,  10kg/drum , 20kg/drum or customized


Specification 

ITEMSSPECIFICATION(USP400)RESULTS
Appearancewhite powder, insipid, innocentQualify
Assay≥98%99.5%
Degree of Substitution2.8-10.55.5
Clarity of solution50%(w/v) water solution is clearclear
Identification(IR) same absorption bands with USP Hydroxypropyl Betadex RSQualify
Loss on Drying≤10%4.5%
 Conductivity10%(w/v) water solution ≤200µS/cm 70
Propylene oxide≤1ppm<0.18ppm
Propylene glycol ≤2.5%0.05% 
Sum of Other Impurities≤1%0.51% 
Betadex≤1.5%0.39%
Residue on Ignition≤0.2%0.09%
Heavy Metal≤20ppm<10ppm
chloride≤0.05%<0.05%
Bacterial endotoxins≤20EU/g<20EU/g
TAMC(cfu/g)≤1000<10
TYMC(cfu/g)≤100<10
Salmonella/E. Coli (cfu/g)AbsentAbsent


Applications

Hydroxypropyl-beta-cyclodextrin  is one of the most widely used cyclodextrin derivatives in current scientific researches and industry applications. It mainly used in food, pharmaceutical and cosmetics industries.

In pharmaceuticals industry, hydroxypropyl-beta-cyclodextrin  can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. hydroxypropyl-beta-cyclodextrin  can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.

In food and perfume industry, hydroxypropyl-beta-cyclodextrin  can enhance the stability of nutritional constituent and extend active time of effective constituent. It can cover up bad smell and bad taste of nutritional constituent. It also can improve production processes and product quality.

In cosmetics industry, hydroxypropyl-beta-cyclodextrin  can reduce stimulate of organic molecular in cosmetic to the skin and mucosa. It can enhance the stability of matter, by preventing oxidation and volatilization of nutrients.